Sometimes I run into new information about a story I’ve previously posted that has changed my mind. This post is an example. I previously wrote about three cancer myths that I concluded were wrong, including that vitamin C is a potentially useful anti-cancer agent. I’ve now read some work that has changed my mind: I think that vitamin C may have anti-cancer activity, and certainly that it should be investigated further. So this post is a changed version of the earlier one, which appeared in June, 2019.… Read the rest “Three cancer myths revisited”
(Vials of SARS-CoV-2 vaccine).
The coronavirus SARS-CoV-2, the cause of COVID-19, has quickly spread and caused devastation throughout the world. The medical science community has responded vigorously, with better treatments, recommended changes in social behavior, and, of particular importance, effective vaccination programs. Of the immunization protocols that have been developed, the novel mRNA-based vaccines have captured the scientific spotlight; they are the first mRNA vaccines to be licensed for human use.
A new way to immunize
In principle, the mechanism by which mRNA vaccines create immunity to SARS-CoV-2 is straightforward.… Read the rest “A BRIEF HISTORY OF MESSENGER RNA”
How are medical discoveries made? In a previous post (“The Art of Scientific Discovery”), I looked at several models by which science has progressed A sharply focused, systematic pursuit led to the discovery of insulin. An accidental observation produced a drug to treat erectile disfunction. Those, and the other examples of medical advances described there involved more-or-less conventional approaches. But there’s an unconventional approach that appeals to people confronting difficult medical issues.… Read the rest “Medical scientists should not self medicate; except when they should”
Three years ago I posted an article called “The Efficiency of the Human Body”, and it has proven to be popular. Then I posted an update last November. I’ve now learned more about the subject, and thought about it, and it’s time for another upgrade. Naturally, upgrades almost always involve an expansion, so there are two pieces now: This one, which explores the distribution of energy use in the resting body (our resting metabolic rate) and the next, which includes the material in the original post by describing energy distribution in the body in motion.… Read the rest “Human Energy: The Body at Rest”
Nutritional scientists break down energy consumption into three components. The largest is Resting Energy Expenditure (REE), which I’ve examined in detail in the previous post. It accounts for 60-80% of our daily energy consumption. REE is the energy consumed at rest, when there’s no physical activity going on. Another 5-10% is used for digestion. The rest of our energy consumption is due to physical activity. These proportions can vary: if you’re a rider in the Tour de France, your daily physical activity will probably exceed your REE several times over.… Read the rest “Human Energy: The Body in motion”
(Electron micrograph of SARS-CoV-2 from NIAID-RML)
It’s difficult to make predictions, especially about the future. That aphorism has been attributed to a long list of prognosticators, including the legendary wordsmith and NY Yankees catcher, Yogi Berra. Yogi was eminently quotable, including such gems as, “When you come to a fork in the road, take it.” But he wasn’t the first people’s scholar to have that insight into the difficulty of making predictions. It was apparently spoken in the Danish parliament, in 1937 or 1938, in Danish.… Read the rest “The future of coronavirus – updated”
As of March 4, 2020 the novel coronavirus SARS-CoV-2, which causes COVID-19, has spread to more than 77 countries. More than 93,000 cases have been reported, and just under 3,200 deaths. It’s thought that the virus infected its first human victim in the city of Wuhan in China, in November, 2019. That case was apparently caused by transmission of SARS-CoV-2 from an animal. Since then, it has spread by human-to-human contact. The virus probably originated in bats, and then likely passed through another animal before it found its human host.… Read the rest “The Drift of Coronavirus”
A death in Minnesota
The young man arrived in the emergency room in Minneapolis, Minnesota in acute distress, with a fever, rapid deep breathing, and a racing heart. As reported in 2018, doctors couldn’t initially identify the cause of his problem (1). His breath had twice the normal level of carbon dioxide, and that level kept going up. His fever also kept increasing, despite the doctors’ frantic efforts to stabilize him. Forty-five minutes after admission the muscles in his body violently seized up, rigor mortis, but in a body not yet dead.… Read the rest “How DNP (dinitrophenol) kills you”
Samuel Hahnemann, father of homeopathic medicine.
A paper published in the June 30, 1988 issue of the high-profile scientific journal Nature shocked the biomedical research world. Its anodyne title, “Human Basophil Degranulation Triggered by Very Dilute Antiserum Against IgE”, probably didn’t cause any non-scientists to choke on their breakfast cereal. But in the eyes of the mainstream scientific world, the article made a radical claim: Pure water, admittedly with a special history, could generate an immune reaction in a test tube.… Read the rest “The Fading Memory of Water”
In April 2017 I published a post titled “Why is there so much talk about Epigenetics?”. I think I did a pretty decent job explaining what Epigenetics is, and why it is such a critically important part of biology. The gist is, that the regulated output of our genomic information depends on Epigenetics. This is achieved by specific chemical groups and protein along the chromosomes that control their expression into the proteins and other products needed for the life of a particular cell.… Read the rest “Why there is so much talk about Epigenetics”