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One of the most tantalizing aspects of cancer biology is this: that the normal immune system often recognizes growing tumors, and even targets them for destruction, but then is silenced. This story is about how to wake it up and mobilize it to greater anti-tumor activity. It is a story that reaches back a hundred years, to the innovative work of an esteemed German biochemist. It was his conviction that he had identified a key feature of cancer that would provide an opening for its treatment.… Read the rest “Cancer Therapy: Old is New Again”

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(C57 Black/6 mouse) Attacking cancer with the immune system is one of the most enticing dreams of cancer researchers and oncologists. This dream has floated in and out of the foreground for over a century; as early as the 1890s, such a mechanism was probably responsible for a number of “miracle” cancer cures, even if the immune system was still much of a mystery. Since then, the dream of cancer immunotherapy has offered up promising results, but has never fully revealed itself.Read the rest “Mice and Men”