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DNA is the bedrock of our genetic identity. It encodes physical and mental traits in our genes and it is generally unchanging and the same in all cells. There are ‘epigenetic’ aspects, some of which are still puzzling, that appear to carry over between generations, which are not due to the modification of DNA sequence. (Other posts have explored epigenetics.) But DNA sequence is the default carrier of our genetic identity.

Although the DNA in our cells is largely unchanging and the same in every cell, neither of those features is strictly true.… Read the rest “the goldilocks zone: Mutation, Cancer, and Evolution”

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One of the most tantalizing aspects of cancer biology is this: that the normal immune system often recognizes growing tumors, and even targets them for destruction, but then is silenced. This story is about how to wake it up and mobilize it to greater anti-tumor activity. It is a story that reaches back a hundred years, to the innovative work of an esteemed German biochemist. It was his conviction that he had identified a key feature of cancer that would provide an opening for its treatment.… Read the rest “Cancer Therapy: Old is New Again”

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Sometimes I run into new information about a story I’ve previously posted that has changed my mind. This post is an example. I previously wrote about three cancer myths that I concluded were wrong, including that vitamin C is a potentially useful anti-cancer agent. I’ve now read some work that has changed my mind: I think that vitamin C may have anti-cancer activity, and certainly that it should be investigated further. So this post is a changed version of the earlier one, which appeared in June, 2019.… Read the rest “Three cancer myths revisited”

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Peter Nowell and David Hungerford in 1960

Chronic Myeloid Leukemia (CML) is not a cancer you hear about very often. That’s not because it isn’t serious — until recently, it carried a frightening prognoses. Until about 2000, newly diagnosed CML patients had a 5-year survival rate of 31%. But we don’t hear much about CML because it is a rare disease, and affects far fewer people than cancers of the breast or prostate, or lung cancer.Read the rest “Chronic Myeloid Leukemia: a Molecular Diagnosis”

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Dr. Brian Druker and Ms. LaDonna Lopossa, one of the earliest patients to benefit from Gleevec

Rob Schick is the Branch Manger of the Baird Wealth Management Group in Portland, Oregon. Most people would probably consider him lucky. For starters, Portland is one of the most desirable cities in the United States to live in. He and his wife have three grown children, one of whom works at the same company. In addition to his success in business, Rob Schick’s efforts on behalf of the Knight Cancer Institute, where he has helped raise millions of dollars for research, were nationally recognized in 2015 by a National Community Service Award from the Invest in Others Foundation.Read the rest “Chronic Myeloid Leukemia: A Molecular Solution”

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If there were a contest to name the most-hated chemical, Roundup, Monsanto’s brand name for the chemical Glyphosate, would have a very good chance of winning. It has been identified not only as a plant poison, but also a destroyer of monarch butterflies, an impoverisher of developing-world farmers, and a probable carcinogen. These are serious issues. But they are also complex, and I will argue, they are not settled (except for being a plant poison).Read the rest “The Trouble With Roundup”

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(C57 Black/6 mouse) Attacking cancer with the immune system is one of the most enticing dreams of cancer researchers and oncologists. This dream has floated in and out of the foreground for over a century; as early as the 1890s, such a mechanism was probably responsible for a number of “miracle” cancer cures, even if the immune system was still much of a mystery. Since then, the dream of cancer immunotherapy has offered up promising results, but has never fully revealed itself.Read the rest “Mice and Men”

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A surprising link has been uncovered between cheese consumption and deaths of women from lung and bronchial cancer. This link is entirely unexpected: doctors had not previously noticed this association. Cheese contains quite a lot of fat, which does apparently have a link to certain cancers, such as breast and bowel cancers. But there hasn’t previously been an association of cheese consumption and lung cancer.

The correlation between lung cancer and cheese production

The data showing the production of cheese in the USA between 1975 and 1995, and the age-adjusted deaths of women from lung cancer are in the following graph (1):

The correlation is striking.Read the rest “Unexpected link between cheese consumption and lung cancer”