biological homology

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Charles Best and Frederick Banting, with one of their research subjects. University of Toronto Archives

This post describes some of the many pathways to scientific discovery. No single model applies to all discoveries, and most discoveries contain elements of different models. I will focus on the field I know best, biomedical research. Biomedical discoveries are usually, but not exclusively, the result of hypothesis- and curiosity-driven “small science”. In contrast, the first report of evidence for the Higgs Boson at the LHC in Switzerland listed over 2500 authors from some 180 institutions, and depended on the construction of a 5 billion dollar supercollider with an annual operating budget of one billion.… Read the rest “THE ART OF SCIENTIFIC DISCOVERY”

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(C57 Black/6 mouse) Attacking cancer with the immune system is one of the most enticing dreams of cancer researchers and oncologists. This dream has floated in and out of the foreground for over a century; as early as the 1890s, such a mechanism was probably responsible for a number of “miracle” cancer cures, even if the immune system was still much of a mystery. Since then, the dream of cancer immunotherapy has offered up promising results, but has never fully revealed itself.… Read the rest “Mice and Men”

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What do you think of when you hear the term “circadian rhythm”? For most of us, it’s “jet lag”, because that’s the way we’ve likely encountered it. But “circadian”, which refers to anything biological that goes through a cycle in about 24 hours, applies to many aspects of the lives of plants, animals, and even bacteria.

A flower led the way

Daily variations in the behaviors of plants and animals have been known about since antiquity.… Read the rest “Circadian Rhythm I – the plant world”

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Some people have a hard time keeping to the conventional clock. They strongly prefer to sleep and stay up late. Some people show the opposite behaviour; they wake up very early, but are ready for bed well before the late evening news. Although there may be exceptions (teenagers and jazz musicians come to mind), both kinds of behaviour are often related to a changed circadian rhythm. Late sleepers are referred to as “delayed phase” in their circadian rhythm, while those who are exceptionally early to bed – early to rise are said to have “Familial Advanced Sleep Phase Syndrome” (FASPS).… Read the rest “Circadian Rhythm II – Us”

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(Microscopic image of C. elegans with Nomarski DIC optics: by permission, Prof. Sander van den Heuvel, Developmental Biology, Universiteit Utrecht. About 200x lifesize.)

How long can we expect to live in the future? The longest recorded human life is that of a French woman, Jeanne Calment, who died aged 122 and a half, in 1997. The eighth oldest, and currently oldest living person, is an Italian woman named Emma Morano, who will be 117 on November 29, 2016.… Read the rest “Life Expectancy II: It’s in the Genes”